Prometrium is a brand-name medication that contains progesterone as its active ingredient. It is available in oral pill form in strengths of 100 mg and 200 mg. In Hong Kong, Prometrium is classified as a prescription (Rx) product and is regulated by the Hong Kong Department of Health - Pharmacy and Poisons Board. Internationally, it is approved by agencies such as the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA) for specific women's health indications.
Progesterone belongs to the hormone class used to support the menstrual cycle, pregnancy, and certain hormone-replacement regimens. Prometrium is manufactured by MannKind Corporation (brand-specific information is publicly listed on the product label).
Progesterone is a natural steroid hormone that prepares the uterus for implantation of a fertilized egg and sustains early pregnancy. When taken orally, Prometrium’s progesterone is absorbed through the gastrointestinal tract and enters the bloodstream, where it binds to progesterone receptors in target tissues:
The medication’s onset of action typically occurs within a few hours of ingestion, with peak plasma concentrations reached in about 1-2 hours. The duration of effect lasts roughly 12-24 hours, supporting once-daily dosing schedules. Oral progesterone undergoes extensive first-pass metabolism in the liver, converting a portion of the dose into inactive metabolites, which is why higher oral doses (e.g., 200 mg) may be needed to achieve therapeutic effects.
Prometrium is approved for the following FDA/EMA-recognized indications, which are generally accepted in Hong Kong clinical practice:
These uses are guided by evidence from randomized controlled trials and clinical guidelines published by societies such as the American Society for Reproductive Medicine (ASRM) and the North American Menopause Society (NAMS).
Some clinicians prescribe progesterone for conditions that are not formally approved but have supporting research:
Disclaimer: These off-label applications are not approved by the FDA, EMA, or Hong Kong regulatory authorities. Use should occur only under the direct supervision of a qualified healthcare provider, with individualized risk assessment.
If any of the above conditions apply, a healthcare professional should evaluate whether Prometrium is appropriate.
Patients should provide a complete medication list, including over-the-counter drugs, supplements, and herbal products, before starting Prometrium.
Dosage must be individualized based on the indication, patient weight, metabolic status, and clinical response. The prescribing physician will determine the exact regimen.
Regular follow-up appointments enable clinicians to assess efficacy, adjust dosing, and monitor for adverse events.
This article provides educational information about Prometrium and is not a substitute for professional medical advice. Treatment decisions, including the use of any medication for unapproved indications, must be made under the guidance of a qualified healthcare provider. The content is intended for informational purposes and does not constitute medical recommendations. Always consult a physician before starting, stopping, or changing any medication regimen.
Prometrium can be used together with combined estrogen-progestin contraceptives, but overlapping hormonal effects may increase breast tenderness. Discuss timing and any needed dose adjustments with your clinician.
Progesterone is a naturally occurring hormone and is not typically screened for in standard workplace or athletic drug tests. However, certain anti-doping agencies may monitor hormone levels; consult your organization’s policies if you compete professionally.
In most markets, the 100 mg tablet bears the imprint “P-100” and the 200 mg tablet “P-200.” Imprints can vary by manufacturer and region; verify the markings against the pharmacy label.
Yes, but keep the medication in its original labeled container, carry a copy of the prescription, and be aware that some countries may require a medical certificate for hormone therapy. Store the pills in a carry-on bag to avoid temperature extremes.
There are no strict dietary restrictions, but taking the pill with a meal can lessen gastrointestinal upset. Avoid excessive alcohol, which can strain liver metabolism.
Progesterone supplementation is sometimes prescribed for women with a history of recurrent miscarriage, but this use is off-label and should only be considered after thorough evaluation by a reproductive specialist.
Typical excipients include lactose, microcrystalline cellulose, and magnesium stearate. Patients with lactose intolerance should verify the formulation with the pharmacist.
Clinical effects on the uterine lining usually become apparent within 2-3 days of daily dosing, though full therapeutic benefit may require several days of consistent use.
Yes, generic oral progesterone tablets are marketed under various brand names. They contain the same active ingredient and dosage strengths, but patients should confirm bioequivalence with their prescriber.
